| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 189260 | Calcium | Small molecule | Small molecule | Increases activity | indirect | Phospholipase C | Family | Homo sapiens-e | | | Neoplastic keratinocyte cell lines expressing
a mutant c-Ha-ras gene and normal keratinocytes transformed
to the neoplastic phenotype by transduction with the
v-Ha-ras gene (v-Ha-ras keratinocytes) have elevated
constitutive activity of PLC that increases further in
response to Ca2+, but the cells do not differentiate normally. | | | |
Interaction id | 189260 | |
MOLECULE A | |
Id | 7440-70-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00011 |
Type | Family |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Second-Messenger-Mediated
Signaling:Calcium-Mediated Signaling | |
Disease Details | | |
Experimental location and method | - condition::Normal keratinocytes
transformed to the neoplastic phenotype by
transduction with the v-Ha-ras gene
- cell::Keratinocytes
| |
References | |
PubMed Id | 8068182 | |
Author | Punnonen K, Denning MF, Rhee SG, Yuspa SH | |
Title | Differences in the regulation of
phosphatidylinositol-specific phospholipase C in normal and
neoplastic keratinocytes. |
|
|
| | |
| 430063 | Phospholipase C | Protein | Homo sapiens | Increases mobilization | indirect | Calcium | Small molecule | Small molecule | | | PAR2 agonists increased intracellular [Ca2+]
([Ca2+]i) in these neurons in culture, and PAR2-responsive
neurons also responded to the TRPV1 agonist capsaicin,
confirming coexpression of PAR2 and TRPV1. PAR2 agonists
potentiated capsaicin-induced increases in [Ca2+]i in
TRPV1-transfected human embryonic kidney (HEK) cells and DRG
neurons and potentiated capsaicin-induced currents in DRG
neurons. / Inhibitors of phospholipase C and protein kinase
C (PKC) suppressed PAR2-induced sensitization of
TRPV1-mediated changes in [Ca2+]i and TRPV1 currents. | | | |
Interaction id | 430063 | |
MOLECULE A | |
Id | EZHsF00011 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Calcium |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Id | 7442 : TRPV1 |
Type | Protein |
Species | Homo sapiens-e | | Induce | | Attribute | Description | | Activated:
| by capsaicin |
|
|
Structure Details | |
Disease Details | | |
Id | 404-86-4 : Capsaicin |
Type | Small molecule |
Species | Small molecule | |
Structure Details | |
Disease Details | | |
Id | 2150 : F2RL1 |
Type | Protein |
Species | Homo sapiens | | Stimulate | | Attribute | Description | | Activated:
| by agonist |
|
|
Structure Details | |
Disease Details | | | Kinetics | - | |
|
General Information |
Interaction term | Increases mobilization (
indirect ) | |
Experimental location and method | - Location context::Interaction specific
- species::Human
- cell / cell line::293
- primary::N
- Location context::Supporting evidence
- organ / tissue::Spinal Ganglia
| |
Comments | |
General | | Referred full text for location-293 cells |
| |
References | |
PubMed Id | 15128844 | |
Author | Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF,
Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis
JB, Mayer EA, Bunnett NW | |
Title | Protease-activated receptor 2 sensitizes the capsaicin
receptor transient receptor potential vanilloid receptor 1 to
induce hyperalgesia. |
|
|
| |
|
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