| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 186898 | Gadolinium | Small molecule | Small molecule | Inhibits expression | indirect | Tnf | Protein | Rattus norvegicus | | | Regulation of Kupffer cell TNF gene
expression during experimental acute pancreatitis: the role
of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB. / TNF and
TNF-mRNA were measured in rat livers perfused with elastase.
/ Elastase increased TNF and upregulated TNF-mRNA in livers
(P<0.03) and Kupffer cells (P<0.001). / Gadolinium
inhibited elastase-induced upregulation of TNF-mRNA (P <
0.001), TNF production (P<0.001), and attenuated
SAPK/JNK, as well as ERK1/2, but not p38-MAPK. Both UO126
and SB203580 significantly inhibited elastase-induced
upregulation of TNF-mRNA and TNF production (P<0.001),
but only UO126 inhibited activation of NF-kappaB. | | | |
Interaction id | 186898 | |
MOLECULE A | |
Id | 7440-54-2 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24835 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Kinetics Data | | Data | Comments | p-value <0.001
| |
|
| |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Disease Details | | |
Experimental location and method | - species::Rat
- condition::ELA1 perfused liver during
experimentally induced acute pancreatitis
- cell::Kupffer cells
- organ / tissue::Liver
| |
References | |
PubMed Id | 12559181 | |
Author | Murr MM, Yang J, Fier A, Gallagher SF, Carter G, Gower WR
Jr, Norman JG | |
Title | Regulation of Kupffer cell TNF gene expression during
experimental acute pancreatitis: the role of p38-MAPK, ERK1/2,
SAPK/JNK, and NF-kappaB. |
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