| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 185325 | Lovastatin | Small molecule | Small molecule | Inhibits expression | indirect | TNF | Protein | Homo sapiens-e | | | In this study, we examined the putative role
of lovastatin in modulation of CD40 expression and its
signaling in cultured microglia. / Furthermore, lovastatin
is able to suppress microglial tumor necrosis factor-alpha,
interleukin (IL)-beta1 and IL-6 production promoted either
by IFN-gamma or by Abeta peptide challenge in the presence
of CD40 cross-linking. | | | |
Interaction id | 185325 | |
MOLECULE A | |
Id | 75330-75-5 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Alzheimer Disease:Neurodegenerative Diseasessignificance: :Decreases risk of Alzheimer | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IFN Gamma Signaling PathwayResponse to Stimulus:Response to Drug | |
Disease Details | | disease: :Alzheimer Disease:Neurodegenerative Diseases |
| |
Experimental location and method | - condition::Upon INFG cross-linking
with CD40 traetment
- cell::Microglia cells
| |
References | |
PubMed Id | 15378516 | |
Author | Townsend KP, Shytle DR, Bai Y, San N, Zeng J, Freeman M,
Mori T, Fernandez F, Morgan D, Sanberg P, Tan J | |
Title | Lovastatin modulation of microglial activation via
suppression of functional CD40 expression. |
|
|
| |
|
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