| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 73195 | APP | Protein | Homo sapiens-e | Increases activity | indirect | c-Jun N-terminal kinase | Family | Homo sapiens | | | Abeta treatment also results in the
activation of c-Jun aminoterminal kinases (JNKs) and
p38(MAPK) and is followed by characteristic nuclear changes
of apoptosis as evaluated by DAPI staining and TUNEL technique. | | | |
Interaction id | 73195 | |
MOLECULE A | |
Id | 351 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00044 |
Type | Family |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | |
Regulation | Positive | | Description | H2O2, 4-hydroxynonenal |
| |
Regulation | Negative | | Description | alpha-tocopherol, N-acetylcysteine |
|
| | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | NeurogenesisApoptosisResponse to Stress:Response to Oxidative Stress | |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - species::Human
- cell::SK-N-BE cells
| |
References | |
PubMed Id | 12684028 | |
Author | Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola
M, Danni O | |
Title | H2O2 and 4-hydroxynonenal mediate amyloid beta-induced
neuronal apoptosis by activating JNKs and p38MAPK. |
|
|
| | |
| 177007 | c-Jun N-terminal kinase | Family | Rattus norvegicus | Increases activity | indirect | Casp3 | Protein | Rattus norvegicus | | | Here, we examine the role of the c-Jun
N-terminal kinases (JNKs) and of their substrate, c-Jun, in
the death of cultured neuronal PC12 cells and sympathetic
neurons evoked by exposure to aggregated A beta. / Finally,
CEP-1347 blocked A beta-stimulated activation of caspase-2
and -3, placing these downstream of JNK activation. These
observations implicate the JNK pathway as a required element
in death evoked by A beta and hence identify it as a
potential therapeutic target in AD. | | | |
Interaction id | 177007 | |
MOLECULE A | |
Id | EZRnF00044 |
Type | Family |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 25402 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Protein Kinase CascadeApoptosis:Caspase Activation | |
Disease Details | | disease: :Alzheimer Disease |
| |
Experimental location and method | - species::Rat
- condition::APP treated cells
- cell::PC12 cells
| |
References | |
PubMed Id | 11279271 | |
Author | Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ,
Shelanski ML, Greene LA | |
Title | beta-Amyloid-induced neuronal apoptosis requires c-Jun
N-terminal kinase activation. |
|
|
| |
|
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