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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
176353MAP2K4ProteinHomo sapiens-eIncreases activitydirectp38 MAPKFamilyHomo sapiens-e
Unlike JNKK1 that activates both JNK and p38 MAP kinases, JNKK2 stimulated only JNK.
176765MAP2K4ProteinHomo sapiens-ePhosphorylatedirectp38 MAPKFamilyHomo sapiens-e
We also found that overexpression of the constitutively active form of SEK1 (SEK1-ED) increases both p38 MAPK and JNK/SAPK phosphorylation, and increases PGE2 production and Cox-2 expression. By comparison, overexpression of the dominant negative form of SEK1 (SEK1-AL) decreases the phosphorylation of both p38 MAPK and JNK/SAPK and reduces Cox-2 expression.