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We also found that overexpression of the
constitutively active form of SEK1 (SEK1-ED) increases both
p38 MAPK and JNK/SAPK phosphorylation, and increases PGE2
production and Cox-2 expression. By comparison,
overexpression of the dominant negative form of SEK1
(SEK1-AL) decreases the phosphorylation of both p38 MAPK and
JNK/SAPK and reduces Cox-2 expression.