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Our experiments demonstrate that
overexpression of DeltaMEKK1 (a constitutively active
truncation mutant of MEKK1 containing the C-terminal 324
amino acids) increases Cox-2 expression and PGE2 production
which is completely blocked by SC68376, a pharmacologic
inhibitor of p38 MAPK.DeltaMEKK1 overexpression results in
activation of both c-Jun N-terminal kinases/extracellular
signal-regulated kinases (JNK/SAPK) and p38 MAPK.