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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
176750MAP3K1ProteinHomo sapiens-eIncreases activityindirectp38 MAPKFamilyHomo sapiens-e
Our experiments demonstrate that overexpression of DeltaMEKK1 (a constitutively active truncation mutant of MEKK1 containing the C-terminal 324 amino acids) increases Cox-2 expression and PGE2 production which is completely blocked by SC68376, a pharmacologic inhibitor of p38 MAPK.DeltaMEKK1 overexpression results in activation of both c-Jun N-terminal kinases/extracellular signal-regulated kinases (JNK/SAPK) and p38 MAPK.