| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 132564 | MAP2K1 | Protein | Homo sapiens-e | Increases activity | direct | MAPK3 | Protein | Homo sapiens-e | | | We report the purification to near
homogeneity of a 45-kDa phorbol ester-stimulated protein
kinase that phosphorylates and activates the Erk-1 gene
product.This kinase, which we provisionally denote MEK for
MAPK/Erk kinase, phosphorylated kinase-inactive Erk-1
protein primarily on a tyrosine residue and, to a lesser
extent, on a threonine. | | | |
Interaction id | 132564 | |
MOLECULE A | |
Id | 5604 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5595 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein kinase cascade:MAPK/ERK signaling pathway | |
References | |
PubMed Id | 1381507 | |
Author | Crews CM, Erikson RL | |
Title | Purification of a murine protein-tyrosine/threonine kinase
that phosphorylates and activates the Erk-1 gene product:
relationship to the fission yeast byr1 gene product. |
|
|
| | |
| 172890 | Map2k1 | Protein | Rattus norvegicus | Increases activity | direct | Mapk3 | Protein | Rattus norvegicus | | | Here we show that in C6 glioma cells,
transiently expressing the dominant-negative form of
c-Ha-Ras (Asn-17) abrogated IFN-gamma-induced ERK1 and ERK2
activation. Furthermore, PD98059, a specific MEK1 inhibitor,
also blocked this activation. These results indicate that
p21ras and MEK1 are required for IFN-gamma-induced ERK1 and
ERK2 activation. | | | |
Interaction id | 172890 | |
MOLECULE A | |
Id | 170851 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 50689 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IFN Gamma Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathwaySmall GTPase Mediated Signal Transduction:RAS
Protein Signal Transduction | |
Experimental location and method | - species::Rat
- condition::IFNG treated cells
- cell::C6 cells
| |
References | |
PubMed Id | 9180263 | |
Author | Nishiya T, Uehara T, Edamatsu H, Kaziro Y, Itoh H, Nomura Y | |
Title | Activation of Stat1 and subsequent transcription of inducible
nitric oxide synthase gene in C6 glioma cells is independent of
interferon-gamma-induced MAPK activation that is mediated by p21ras. |
|
|
| | |
| 172891 | Map2k1 | Protein | Rattus norvegicus | Increases activity | direct | Mapk1 | Protein | Rattus norvegicus | | | Here we show that in C6 glioma cells,
transiently expressing the dominant-negative form of
c-Ha-Ras (Asn-17) abrogated IFN-gamma-induced ERK1 and ERK2
activation. Furthermore, PD98059, a specific MEK1 inhibitor,
also blocked this activation. These results indicate that
p21ras and MEK1 are required for IFN-gamma-induced ERK1 and
ERK2 activation. | | | |
Interaction id | 172891 | |
MOLECULE A | |
Id | 170851 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 116590 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Small GTPase Mediated Signal Transduction:RAS
Protein Signal TransductionCytokine And Chemokine Mediated Signaling
Pathway:IFN Gamma Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathway | |
Experimental location and method | - species::Rat
- condition::IFNG treated cells
- cell::C6 cells
| |
References | |
PubMed Id | 9180263 | |
Author | Nishiya T, Uehara T, Edamatsu H, Kaziro Y, Itoh H, Nomura Y | |
Title | Activation of Stat1 and subsequent transcription of inducible
nitric oxide synthase gene in C6 glioma cells is independent of
interferon-gamma-induced MAPK activation that is mediated by p21ras. |
|
|
| | |
| 210987 | CCL2 | Protein | Homo sapiens-e | Increases activity | indirect | MAP2K1 | Protein | Homo sapiens-e | | | 1. The present study was aimed to investigate
the effect of benzydamine, an anti-inflammatory drug devoid
of activity on arachidonic acid metabolism, on monocyte
chemotaxis and to define the possible biochemical correlates
of activity. 2. Benzydamine inhibited monocyte chemotaxis in
response to three classes of chemoattractants: the
prototypic CC-chemokine CCL2 (MCP-1), the microbial product
fMLP and the complement cascade component C5a. / Benzydamine
strongly inhibited chemoattractant-induced activation of the
mitogen-activated protein kinase (MAPK) ERK1/2, and of its
upstream activator kinase MEK1/2. ERK1/12 activation in
response to chemoattractants was 89-98% inhibited by a 100
microm concentration of benzydamine with an IC50 of 30 microm. | | | |
Interaction id | 210987 | |
MOLECULE A | |
Id | 6347 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5604 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Response to Stimulus:Response to DrugCytokine And Chemokine Mediated Signaling Pathway | |
Experimental location and method |
| |
References | |
PubMed Id | 12970098 | |
Author | Riboldi E, Frascaroli G, Transidico P, Luini W, Bernasconi
S, Mancini F, Guglielmotti A, Milanese C, Pinza M, Sozzani S,
Mantovani A | |
Title | Benzydamine inhibits monocyte migration and MAPK activation
induced by chemotactic agonists. |
|
|
| |
|
d: for diseases
Regulator