| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 14835 | IL1R1 | Protein | Homo sapiens | Bind | direct | RAC1 | Protein | Homo sapiens | | | Glutathione S-transferase (GST) fusion
proteins, containing either the full-length IL-1R cytosolic
domain (GST-IL-1Rcd) or the terminal 68 amino acids of IL-1R
required for IL-1-dependent signal transduction,
specifically coprecipitated both RhoA and Rac-1, but not
p21(ras), from Triton-soluble HeLa cell extracts. | | | |
Interaction id | 14835 | |
MOLECULE A | |
Id | 3554 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5879 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:IL1 Signaling Pathway | |
Disease Details | | |
Experimental location and method | - Experimental method::Immunoprecipitation
- species::Human
- cell::HeLa cells
| |
Comments | |
Domain_motif_site_residue | | (PF01582)[RES:Terminal 68 amino acids](IL1R1) |
| |
References | |
PubMed Id | 10359565 | |
Author | Singh R, Wang B, Shirvaikar A, Khan S, Kamat S, Schelling
JR, Konieczkowski M, Sedor JR | |
Title | The IL-1 receptor and Rho directly associate to drive cell
activation in inflammation. |
|
|
| | |
| 129994 | RAC1 | Protein | Homo sapiens-e | Increases activity | indirect | p38 MAPK | Family | Homo sapiens-e | | | Constitutively activated forms of Rac and
Cdc42Hs are efficient activators of a cascade leading to JNK
and p38/Mpk2 activation. | | | |
Interaction id | 129994 | |
MOLECULE A | |
Id | 5879 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | EZHsF00051 |
Type | Family |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Small GTPase Mediated Signal Transduction:RAC
Protein Signal Transduction | |
References | |
PubMed Id | 7600582 | |
Author | Minden A, Lin A, Claret FX, Abo A, Karin M | |
Title | Selective activation of the JNK signaling cascade and c-Jun
transcriptional activity by the small GTPases Rac and Cdc42Hs. |
|
|
| | |
| 172637 | Rac1 | Protein | Mus musculus | Increases activity | direct | Map3k1 | Protein | Mus musculus | | | We investigate here the transcriptional
activation of the murine PGS2 gene in NIH 3T3 cells, in
response to the mitogens platelet-derived growth factor
(PDGF) or serum. / Cotransfection of plasmids expressing
dominant-negative Ras, Rac1, MEKK-1, or JNK along with the
[PGS2][luciferase] reporter prevents induction by PDGF or
serum, demonstrating that serum and PDGF induction of the
PGS2 gene in NIH 3T3 cells requires activation of a
Ras/Rac1/MEKK-1/JNK kinase/JNK signal transduction leading
to phosphorylation of c-Jun. | | | |
Interaction id | 172637 | |
MOLECULE A | |
Id | 19353 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 26401 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Transmembrane Receptor Protein Tyrosine Kinase
Signaling Pathway:Platelet-Derived Growth Factor
Receptor Signaling PathwaySmall GTPase Mediated Signal Transduction:RAC
Protein Signal Transduction | |
Interaction result | |
Other Resultant | | Leads to activation of Jnkk and
increased activation of Ptgs2 gene |
| |
Experimental location and method | - Experimental method::Dominant negative analysis
- species::Mouse
- condition::Platelet-derived growth
factor treated cells
- cell::NIH3T3 cells
| |
Comments | |
Property | | Dominant negative molecule:Rac1 |
| |
References | |
PubMed Id | 8940199 | |
Author | Xie W, Herschman HR | |
Title | Transcriptional regulation of prostaglandin synthase 2 gene
expression by platelet-derived growth factor and serum. |
|
|
| |
|
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