| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 166347 | Phospholipase C | Family | Rattus norvegicus | Increases level | indirect | Inositol 3-phosphate | Small molecule | Small molecule | | | Stimulation of inositol phosphate formation
in ROS 17/2.8 cell membranes by guanine nucleotide, calcium,
and parathyroid hormone. / The nonhydrolyzable guanine
nucleotide, GTP gamma S, and calcium ion, alone and
together, stimulated all three IPs, IP1, IP2, and IP3. IP1
formation was linear over 30 minutes but IP2 and IP3
accumulated more rapidly peaking by 5 minutes for all
agonist conditions. / The results demonstrate that inositol
phosphate formation can be stimulated directly in a membrane
preparation of ROS cells by GTP gamma S, calcium ion, and
PTH and that the enzyme mediating this activity,
phospholipase C, is regulated by a guanine nucleotide
binding protein. | | | |
Interaction id | 166347 | |
MOLECULE A | |
Id | EZRnF00011 |
Type | Family |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Inositol 3-phosphate |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases level (
indirect ) | |
Pathway | Second-Messenger-Mediated Signaling:cGMP-Mediated SignalingHydrolase activity:Phospholipase C activityHormone-Mediated SignalingSecond-Messenger-Mediated
Signaling:Calcium-Mediated Signaling | |
Experimental location and method | - species::Rat
- condition::PTH or Calcium(ion or
Guanosine 5'-O-3-Thiotriphosphate treated cells
- cell::ROS17/2.8 cells
- sub cellular::Plasma membrane
| |
References | |
PubMed Id | 2763877 | |
Author | Cosman F, Morrow B, Kopal M, Bilezikian JP | |
Title | Stimulation of inositol phosphate formation in ROS 17/2.8
cell membranes by guanine nucleotide, calcium, and parathyroid hormone. |
|
|
| | |
| 167632 | Inositol 1,4,5-trisphosphate | Small molecule | Small molecule | Increases mobilization | indirect | Calcium | Small molecule | Small molecule | | | We examined the physiological relevance of
cADPR to the messenger role in stimulation-secretion
coupling in bovine adrenal chromaffin cells. In
digitonin-permeabilized cells, cADPR-induced Ca2+ release
but not caffeine-, ryanodine-, and IP3-induced Ca2+ release
was inhibited by FK506 which bind to FKBP and dissociate it
from the RyR. | | | |
Interaction id | 167632 | |
MOLECULE A | |
Id | 85166-31-0 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Calcium |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases mobilization (
indirect ) | |
Pathway | G-Protein Coupled Receptor Protein Signaling PathwaySecond-Messenger-Mediated
Signaling:Phosphoinositide-Mediated Signaling | |
Experimental location and method | - species::Cow
- condition::Digitonin permeabilized cells
- cell::BACC cells
| |
References | |
PubMed Id | 12491793 | |
Author | Morita K, Kitayama S, Dohi T | |
Title | [Physiological role of cyclic ADP-ribose as a novel
endogenous agonist of ryanodine receptor in adrenal chromaffin cells] |
|
|
| |
|
d: for diseases
