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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
166526SuraminSmall moleculeSmall moleculeInhibits levelindirectCalciumSmall moleculeSmall molecule
Suramin inhibits beta-bungarotoxin-induced activation of N-methyl-D-aspartate receptors and cytotoxicity in primary neurons. / In conclusion, the novel finding of this study was that a polypeptide beta-BuTX exerted a potent cytotoxic effect through sequential events, including activating NMDA receptors followed by increasing [Ca2+]i, ROS production, and impaired mitochondrial energy metabolism. Suramin, clinically used as a trypanocidal agent, was an effective antagonist against beta-BuTX.

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