| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 166347 | Phospholipase C | Family | Rattus norvegicus | Increases level | indirect | Inositol 3-phosphate | Small molecule | Small molecule | | | Stimulation of inositol phosphate formation
in ROS 17/2.8 cell membranes by guanine nucleotide, calcium,
and parathyroid hormone. / The nonhydrolyzable guanine
nucleotide, GTP gamma S, and calcium ion, alone and
together, stimulated all three IPs, IP1, IP2, and IP3. IP1
formation was linear over 30 minutes but IP2 and IP3
accumulated more rapidly peaking by 5 minutes for all
agonist conditions. / The results demonstrate that inositol
phosphate formation can be stimulated directly in a membrane
preparation of ROS cells by GTP gamma S, calcium ion, and
PTH and that the enzyme mediating this activity,
phospholipase C, is regulated by a guanine nucleotide
binding protein. | | | |
Interaction id | 166347 | |
MOLECULE A | |
Id | EZRnF00011 |
Type | Family |
Species | Rattus norvegicus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Inositol 3-phosphate |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases level (
indirect ) | |
Pathway | Second-Messenger-Mediated Signaling:cGMP-Mediated SignalingHydrolase activity:Phospholipase C activityHormone-Mediated SignalingSecond-Messenger-Mediated
Signaling:Calcium-Mediated Signaling | |
Experimental location and method | - species::Rat
- condition::PTH or Calcium(ion or
Guanosine 5'-O-3-Thiotriphosphate treated cells
- cell::ROS17/2.8 cells
- sub cellular::Plasma membrane
| |
References | |
PubMed Id | 2763877 | |
Author | Cosman F, Morrow B, Kopal M, Bilezikian JP | |
Title | Stimulation of inositol phosphate formation in ROS 17/2.8
cell membranes by guanine nucleotide, calcium, and parathyroid hormone. |
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| |
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d: for diseases
