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Previously, we demonstrated that the
anti-inflammatory drug chloroquine (CQ) inhibited
LPS-induced TNF-alpha transcription. / These findings were
supported by functional data demonstrating that CQ and
PD98059 interfered with TNF expression in several human and
murine cell types while neither inhibitor blocked TNF
production in murine RAW264.7 macrophages, a cell line that
does not require MEK-ERK signaling for TNF production.