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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
156199ChloroquineSmall moleculeSmall moleculeInhibits expressionindirectTNFProteinHomo sapiens
Previously, we demonstrated that the anti-inflammatory drug chloroquine (CQ) inhibited LPS-induced TNF-alpha transcription. / These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages, a cell line that does not require MEK-ERK signaling for TNF production.