| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 74966 | Pioglitazone | Small molecule | Small molecule | Increases activity | direct | PPARG | Protein | Homo sapiens | | | Troglitazone and pioglitazone, which are
ligands/activators for PPARgamma, also induced PPARalpha
gene and protein expression and increased CuZn-SOD gene
expression and protein levels in addition to increasing
PPARgamma gene and protein expression in endothelial cells. | | | |
Interaction id | 74966 | |
MOLECULE A | |
Id | 111025-46-8 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Ligand-dependent nuclear receptor
activity:Peroxisome proliferator associated receptor activity | |
Experimental location and method | - species::Human
- cell::Umbilical vein endothelial cells,
human aorta endothelial cells
| |
References | |
PubMed Id | 11172467 | |
Author | Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari
S, Komoda T, Katayama S | |
Title | The ligands/activators for peroxisome proliferator-activated
receptor alpha (PPARalpha) and PPARgamma increase
Cu2+,Zn2+-superoxide dismutase and decrease p22phox message
expressions in primary endothelial cells. |
|
|
| | |
| 75573 | Troglitazone | Small molecule | Small molecule | Increases activity | direct | PPARG | Protein | Homo sapiens-e | | | The PPARgamma agonists 15dPGJ(2),
trogliltazone (TGZ), and GW7845, a synthetic and highly
selective tyrosine-based PPARgamma agonist, all increased
transcriptional activity of PPARgamma, and expression of
CD36, a PPARgamma-dependent gene. | | | |
Interaction id | 75573 | |
MOLECULE A | |
Id | 97322-87-7 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Ligand-dependent nuclear receptor
activity:Peroxisome proliferator associated receptor activity | |
References | |
PubMed Id | 12401880 | |
Author | Clay CE, Monjazeb A, Thorburn J, Chilton FH, High KP | |
Title | 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does
not require PPARgamma in breast cancer cells. |
|
|
| | |
| 79772 | Rosiglitazone | Small molecule | Small molecule | Increases activity | indirect | PPARG | Protein | Homo sapiens | | | Activation of PPARgamma by rosiglitazone or
pioglitazone significantly reduced TNF-alpha and PMA induced
MMP-9 gelatinolytic activity in a concentration dependent
manner in both cell lines, but did not alter the expression
of tissue inhibitor of MMPs type 1 (TIMP-1), the local
inhibitor of MMP-9. | | | |
Interaction id | 79772 | |
MOLECULE A | |
Id | 122320-73-4 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Ligand-dependent nuclear receptor
activity:Peroxisome proliferator associated receptor activity | |
Experimental location and method | - species::Human
- cell::NL20, BEAS cells
| |
References | |
PubMed Id | 12947137 | |
Author | Hetzel M, Walcher D, Grub M, Bach H, Hombach V, Marx N | |
Title | Inhibition of MMP-9 expression by PPARgamma activators in
human bronchial epithelial cells. |
|
|
| | |
| 153661 | Indomethacin | Small molecule | Small molecule | Increases activity | indirect | PPARG | Protein | Homo sapiens-e | | | Furthermore, indomethacin-induced p38
MAPK-mediated apoptosis of colon cancer cell lines is
independent of caspase activation and not associated with
indomethacin-induced NF-kappaB suppression and PPARgamma activation. | | | |
Interaction id | 153661 | |
MOLECULE A | |
Id | 53-86-1 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5468 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | | |
Experimental location and method |
| |
References | |
PubMed Id | 12485869 | |
Author | Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, Kim WH | |
Title | The role of mitogen-activated protein kinases and their
relationship with NF-kappaB and PPARgamma in
indomethacin-Induced apoptosis of colon cancer cells. |
|
|
| |
|
d: for diseases
