| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 152705 | Pioglitazone hydrochloride | Small molecule | Small molecule | Inhibits expression | indirect | Tnf | Protein | Rattus norvegicus | | | Activation of retinoic X receptor and
peroxisome proliferator-activated receptor-gamma inhibits
nitric oxide and tumor necrosis factor-alpha production in
rat Kupffer cells. / An RXR-specific agonist, Ro47-5944, and
a PPAR gamma-specific agonist, AD4833 (pioglitazone
hydrochloride), each inhibited LPS-induced NO and TNF-alpha
production. The combined treatment of Ro47-5944 and AD4833
resulted in enhanced inhibition, and suppressed the mRNA
levels of NO and TNF-alpha. | | | |
Interaction id | 152705 | |
MOLECULE A | |
Id | 112529-15-4 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 24835 |
Type | Protein |
Species | Rattus norvegicus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Ligand-dependent nuclear receptor
activity:Peroxisome proliferator associated receptor activity | |
Disease Details | | disease: :Shock, Septic:Liver injury |
| |
Experimental location and method | - species::Rat
- condition::Lipopolysaccharide treated cells
- cell::Kupffer cells
| |
References | |
PubMed Id | 11124825 | |
Author | Uchimura K, Nakamuta M, Enjoji M, Irie T, Sugimoto R, Muta
T, Iwamoto H, Nawata H | |
Title | Activation of retinoic X receptor and peroxisome
proliferator-activated receptor-gamma inhibits nitric oxide and
tumor necrosis factor-alpha production in rat Kupffer cells. |
|
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| |
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