| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 148222 | Map2k2 | Protein | Mus musculus | Increases activity | direct | Mapk1 | Protein | Mus musculus | | | Estradiol-induced phosphorylation of ERK1/2
in explants of the mouse cerebral cortex: the roles of heat
shock protein 90 (Hsp90) and MEK2. / Surprisingly, MEK2 but
not MEK1 was the principal mediator of estradiol-induced
activation of ERK. Our data demonstrate the requirement for
Hsp90 in estrogen-induced activation of ERK1 and ERK2 by
MEK2 in the developing mouse cerebral cortex and also
provide insight into alternative mechanisms by which
estradiol may influence cytoplasmic and nuclear events in
responsive neurons via the MAP kinase cascade. | | | |
Interaction id | 148222 | |
MOLECULE A | |
Id | 26396 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 26413 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Intracellular Receptor-Mediated Signaling
Pathway:Estrogen Receptor Signaling PathwayProtein kinase cascade:MAPK/ERK signaling pathway | |
Experimental location and method | - species::Mouse
- condition::Estradiol-17beta treated
cerebral cortex explant
- organ / tissue::Cerebral cortex
| |
References | |
PubMed Id | 11748628 | |
Author | Setalo G Jr, Singh M, Guan X, Toran-Allerand CD | |
Title | Estradiol-induced phosphorylation of ERK1/2 in explants of
the mouse cerebral cortex: the roles of heat shock protein 90
(Hsp90) and MEK2. |
|
|
| | |
| 148223 | Map2k2 | Protein | Mus musculus | Increases activity | direct | Mapk3 | Protein | Mus musculus | | | Estradiol-induced phosphorylation of ERK1/2
in explants of the mouse cerebral cortex: the roles of heat
shock protein 90 (Hsp90) and MEK2. / Surprisingly, MEK2 but
not MEK1 was the principal mediator of estradiol-induced
activation of ERK. Our data demonstrate the requirement for
Hsp90 in estrogen-induced activation of ERK1 and ERK2 by
MEK2 in the developing mouse cerebral cortex and also
provide insight into alternative mechanisms by which
estradiol may influence cytoplasmic and nuclear events in
responsive neurons via the MAP kinase cascade. | | | |
Interaction id | 148223 | |
MOLECULE A | |
Id | 26396 |
Type | Protein |
Species | Mus musculus | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 26417 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
direct ) | |
Pathway | Protein kinase cascade:MAPK/ERK signaling pathwayIntracellular Receptor-Mediated Signaling
Pathway:Estrogen Receptor Signaling Pathway | |
Experimental location and method | - species::Mouse
- condition::Estradiol-17beta treated
cerebral cortex explant
- organ / tissue::Cerebral cortex
| |
References | |
PubMed Id | 11748628 | |
Author | Setalo G Jr, Singh M, Guan X, Toran-Allerand CD | |
Title | Estradiol-induced phosphorylation of ERK1/2 in explants of
the mouse cerebral cortex: the roles of heat shock protein 90
(Hsp90) and MEK2. |
|
|
| | |
| 210990 | CCL2 | Protein | Homo sapiens-e | Increases activity | indirect | MAP2K2 | Protein | Homo sapiens-e | | | 1. The present study was aimed to investigate
the effect of benzydamine, an anti-inflammatory drug devoid
of activity on arachidonic acid metabolism, on monocyte
chemotaxis and to define the possible biochemical correlates
of activity. 2. Benzydamine inhibited monocyte chemotaxis in
response to three classes of chemoattractants: the
prototypic CC-chemokine CCL2 (MCP-1), the microbial product
fMLP and the complement cascade component C5a. / Benzydamine
strongly inhibited chemoattractant-induced activation of the
mitogen-activated protein kinase (MAPK) ERK1/2, and of its
upstream activator kinase MEK1/2. ERK1/12 activation in
response to chemoattractants was 89-98% inhibited by a 100
microm concentration of benzydamine with an IC50 of 30 microm. | | | |
Interaction id | 210990 | |
MOLECULE A | |
Id | 6347 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 5605 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases activity (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling PathwayResponse to Stimulus:Response to Drug | |
Experimental location and method |
| |
References | |
PubMed Id | 12970098 | |
Author | Riboldi E, Frascaroli G, Transidico P, Luini W, Bernasconi
S, Mancini F, Guglielmotti A, Milanese C, Pinza M, Sozzani S,
Mantovani A | |
Title | Benzydamine inhibits monocyte migration and MAPK activation
induced by chemotactic agonists. |
|
|
| |
|
d: for diseases
Regulator