To Browse through specific lists, the search terms can be prefixed with following letters: d: for diseases m: for molecules p: for pathways c: for cell lines v: for interaction terms
In this article, we describe the results of
studies designed to determine the extent to which IL-10
contributes to the suppression of TNF-alpha generation from
LPS-stimulated human monocytes evoked by 8-bromo cyclic AMP
(8-Br-cAMP), rolipram, salbutamol, and prostaglandin E2
(PGE2). / LPS evoked a time- and concentration-dependent
generation of TNF-alpha (t1/2 = 4.5 h; EC50 = 273 pg/mL),
which was inhibited by exogenous human recombinant (h) IL-10
(IC50 = 124 pg/mL), and by rolipram (EC50 = 420 nM),
8-Br-cAMP (EC50 = 77 (microM), PGE2 (EC50 = 15 nM) and
salbutamol (EC50 = 20 nM).
Interleukin-10 does not mediate the inhibitory effect of
PDE-4 inhibitors and other cAMP-elevating drugs on
lipopolysaccharide-induced tumors necrosis factor-alpha
generation from human peripheral blood monocytes.