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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
138183PLA2G4AProteinHomo sapiensIncreases activityindirectPPARGProteinHomo sapiens
Overexpression of cPLA(2), but not group IIA sPLA(2) in the HepG2 cells, caused a significantly increased PPAR-alpha/gamma-mediated reporter activity. / Antisense inhibition of cPLA(2) resulted in a significantly decreased PPAR-alpha/gamma activity. The PPAR-alpha/gamma-induced gene transcription in the HepG2 cells was inhibited by the cPLA(2) inhibitors methyl arachidonyl fluorophosphonate and arachidonyltrifluoromethyl ketone, but not by the sPLA(2) inhibitor LY311727. / The cPLA(2)-mediated PPAR activation was likely mediated by arachidonic acid and prostaglandin E(2). / The cPLA(2) thus may represent a potential therapeutic target for the control of PPAR-related liver and metabolic disorders such as obesity, lipid metabolic disorders, diabetes mellitus, and atherosclerosis.
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