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Chronic administration of the
phosphodiesterase (PDE) inhibitors rolipram or papaverine
also increased expression of CREB mRNA in hippocampus,
demonstrating a role for the cAMP cascade. / We have found
that levels of brain-derived neurotrophic factor (BDNF) and
trkB mRNA are also increased by administration of
antidepressants or PDE inhibitors.