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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
129764PapaverineSmall moleculeSmall moleculeIncreases expressionindirectBdnfRNARattus norvegicus
Chronic administration of the phosphodiesterase (PDE) inhibitors rolipram or papaverine also increased expression of CREB mRNA in hippocampus, demonstrating a role for the cAMP cascade. / We have found that levels of brain-derived neurotrophic factor (BDNF) and trkB mRNA are also increased by administration of antidepressants or PDE inhibitors.