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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
2239TNFProteinHomo sapiens-eIncreases expressionindirectCebpbProteinMus musculus
In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma.
6347TNFProteinHomo sapiens-eIncreases expressionindirectNFKB2ProteinHomo sapiens
The results demonstrate that LPS, IL-1beta, and TNF-alpha induce p100 expression at mRNA and protein level while IFN-gamma, IL-3 and IL-4/IL-10 have no effect.The induction of p100 expression was shown to be mediated by a two-fold increase in the p100 transcription rate and a two-fold increase in p100 mRNA stability.
9094TNFProteinHomo sapiens-eIncreases expressionindirectPTGS2ProteinHomo sapiens-e
These studies demonstrated that IL-1beta, TNFalpha, IL-6, but not IFN-gamma increase the expression of Cox-2, whereas they all increase the expression of HCK and FAK.
21252APPProteinHomo sapiens-eIncreases expressionindirectTNFRNAHomo sapiens-e
As a direct test of the requirement for IL-1 in tau phosphorylation and synaptophysin expression, IL-1 actions in neuron-microglia cocultures were manipulated. Activation of microglia with secreted beta-amyloid precursor protein or lipopolysaccharide elevated their expression of IL-1alpha, IL-1beta, and tumor necrosis factor alpha (TNFalpha) mRNA.
Disease
23171TNFProteinHomo sapiens-eIncreases expressionindirectCCL20RNAHomo sapiens
The expression of MIP-3alpha was upregulated by infection with Actinobacillus actinomycetemcomitans and by stimulation with lipopolysaccharide and TNF-alpha.
Disease
34098TNFProteinHomo sapiens-eIncreases expressionindirectPLA2G4ARNAHomo sapiens
Phospholipase A(2) (PLA(2)) is a growing family of enzymes that may play a major role in inflammation / The cells were stimulated with TNF-alpha or IFN-gamma for different lengths of time (1, 4, 18, and 48 h), and the mRNA levels of the different PLA(2) types were determined by reverse transcriptase-PCR (RT-PCR) and normalized to those of the housekeeping gene, GAPDH. In both cell lines, TNF-alpha increased the expression of PLA(2) IVA and IVC, and IFN-gamma increased the expression of PLA(2) IIA and IID.
Disease
53494TNFProteinHomo sapiens-eIncreases activityindirectNF-kappa-BMulti subunitHomo sapiens-e
TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytes. / Late Erk1/2 activation was involved in TNF-alpha-stimulated NF-kappa B activation and cytokine induction.
56392TNFProteinHomo sapiens-eIncreases expressionindirectIL1BProteinHomo sapiens-e
Our data shows that transfection of DCs with recombinant adenovirus AdV-TNF-alpha resulted in greater maturation of the DCs than occurred with control DCs cultured in exogenous TNF-alpha, as determined by up-regulated expression of pro-inflammatory cytokines (e.g. interleukins 1beta and 18), chemokines [e.g. interferon-gamma-inducible protein-10 and macrophage inflammatory protein-1beta (MIP-1beta)], the CC chemokine receptor CCR7, and immunologically important cell surface molecules (CD40, CD86 and intercellular adhesion molecule-1).
Disease
57364TNFProteinHomo sapiens-eIncreases expressionindirectFasProteinMus musculus
Fas is constitutively expressed by primary murine microglia at a low level and significantly up-regulated by TNF-alpha or IFN-gamma stimulation. / TNF-alpha and IFN-gamma induced Fas mRNA by approximately 20-fold.
67585TNFProteinHomo sapiens-eIncreases expressionindirectCD83ProteinHomo sapiens
However, treatment of dendritic cells with tumor necrosis factor-alpha (TNF-alpha) significantly increased the levels of CD83 transcripts and induced CD83 protein expression in dendritic cells.
79168TNFProteinHomo sapiens-eIncreases activityindirectProtein kinase, cAMP-dependent, catalytic subunitSubunit groupHomo sapiens
Consistent with the hypothesis that TNF-alpha induces perilipin hyperphosphorylation by activating PKA, TNF-alpha increased intracellular cAMP approximately 1.7-fold, and the increase was abrogated by PD98059.
128302TNFProteinHomo sapiens-eIncreases expressionindirectCCL2ProteinHomo sapiens
The findings presented herein demonstrate that both human astroglioma cell lines and primary human astrocytes express the CXC chemokines IP-10 and IL-8 and the CC chemokines MCP-1 and RANTES in response to TNF-alpha and IL-1beta.
Regulator
206331TNFProteinHomo sapiens-eIncreases expressionindirectIL1ARNAHomo sapiens
We investigated the involvement of mitogen-activated protein kinases (MAPKs) in the maturation of CD83(-) dendritic cells (DC) derived from human blood monocytes. / Likewise, SB203580 partially prevented the up-regulation of IL-1alpha, IL-1beta, IL-lRa, and TNF-alpha mRNA upon stimulation with LPS and TNF-alpha, as well as the release of bioactive TNF-alpha induced by LPS.
Regulator
232089TNFProteinHomo sapiens-eIncreases expressionindirectTNFAIP2RNAHomo sapiens
We utilized cDNA representational difference analysis to identify the genes in which expression is induced by the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in primary human bronchial epithelial cells and hence are relevant to airway inflammation. Hybridization of the subtraction product to arrayed cDNAs indicated that known tumor necrosis factor-alpha- and interleukin-1beta-inducible genes such as B94, Zfp36, and regulated on activation normal T cell expressed and secreted were represented, confirming the success of the subtraction experiment.
431823TNFProteinHomo sapiens-eIncreases expressionindirectNFKB1RNAHomo sapiens-e
We investigated the regulatory effect of highly N-acetylated COS (NACOS) on tumor necrosis factor-alpha (TNF-alpha)-induced endothelial cell (EC) E-selectin expression, which is crucial for leukocyte recruitment. / Pre-treating ECs with NACOS inhibited the TNF-alpha-induced p65 and p50 mRNA expressions.

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