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Here we show that primary cultures of human
preadipocytes constitutively produce three chemokines,
interleukin-8 (IL-8), macrophage inflammatory protein-1alpha
(MIP-1alpha) and monocyte chemotactic protein-1 (MCP-1),
while their level of expression is low in mature adipocytes.
/ Prolonged stimulation of cultured human adipocytes with
exogenous chemokines leads to a decrease in lipid content in
association with the downregulation of PPARgamma mRNA expression.