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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
125214PirfenidoneSmall moleculeSmall moleculeDecreases expressionindirectTnfProteinMus musculus
In RAW264.7 cells, a murine macrophage-like cell line, pirfenidone suppressed the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) by a translational mechanism, which was independent of activation of the mitogen-activated protain kinase (MAPK) 2, p38 MAP kinase, and c-Jun N-terminal kinase (JNK).
Disease