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In RAW264.7 cells, a murine macrophage-like
cell line, pirfenidone suppressed the proinflammatory
cytokine tumor necrosis factor-alpha (TNF-alpha) by a
translational mechanism, which was independent of activation
of the mitogen-activated protain kinase (MAPK) 2, p38 MAP
kinase, and c-Jun N-terminal kinase (JNK).