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Interaction IDMol ATypeSpeciesVerbNatureMol BTypeSpecies
121720NF-kappa-BMulti subunitHomo sapiensIncreases activitydirectNFKB1DNAHomo sapiens
Ku antigen, RBP-Jk and p50 were found to bind to the DNA region containing the kB element in the p50 promoter. / mRNA expression and de novo synthesis of p50 were inhibited in cells transfected with the mutated gene expression constructs for IkBa, Ku80 and RBP-Jk. A reporter assay demonstrated that p50 transcription was positively mediated by NF-kB, Ku antigen and RBP-Jk, and that the binding elements for these proteins are required for optimal p50 expression.