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These results indicate that the activation of
TrkB by BDNF induces the activation of PI3-K via IRS-1 and
-2 rather than by a direct interaction of TrkB with PI3-K in
cultured cortical neurons.
Yamada M, Ohnishi H, Sano S, Nakatani A, Ikeuchi T,
Hatanaka H
Title
Insulin receptor substrate (IRS)-1 and IRS-2 are
tyrosine-phosphorylated and associated with phosphatidylinositol
3-kinase in response to brain-derived neurotrophic factor in
cultured cerebral cortical neurons.