| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 23171 | TNF | Protein | Homo sapiens-e | Increases expression | indirect | CCL20 | RNA | Homo sapiens | | | The expression of MIP-3alpha was upregulated
by infection with Actinobacillus actinomycetemcomitans and
by stimulation with lipopolysaccharide and TNF-alpha. | | | |
Interaction id | 23171 | |
MOLECULE A | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6364 |
Type | RNA |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | disease: :Oral squamous carcinomaexpression: :High | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Experimental location and method | - Experimental method::Polymerase Chain Reaction
- species::Human
- cell::SCC-9, SAS, BSC-OF, HSC-4, HSC,
Ca9-22 cells
| |
References | |
PubMed Id | 12642237 | |
Author | Abiko Y, Nishimura M, Kusano K, Nakashima K, Okumura K,
Arakawa T, Takuma T, Mizoguchi I, Kaku T | |
Title | Expression of MIP-3alpha/CCL20, a macrophage inflammatory
protein in oral squamous cell carcinoma. |
|
|
| | |
| 115496 | CCL20 | Protein | Homo sapiens | Increases mobilization | indirect | Calcium | Small molecule | Small molecule | | | In contrast to other chemokines, including
MCP-1 and IL-8, the natural processing did not affect the
calcium-mobilizing capacity of LARC/MIP-3alpha through its
receptor CCR6. | | | |
Interaction id | 115496 | |
MOLECULE A | |
Id | 6364 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | Calcium |
Type | Small molecule |
Species | Small molecule | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | |
Regulator | | | Kinetics | - | |
|
General Information |
Interaction term | Increases mobilization (
indirect ) | |
Pathway | Cytokine And Chemokine Mediated Signaling Pathway | |
References | |
PubMed Id | 11035086 | |
Author | Schutyser E, Struyf S, Menten P, Lenaerts JP, Conings R,
Put W, Wuyts A, Proost P, Van Damme J | |
Title | Regulated production and molecular diversity of human liver
and activation-regulated chemokine/macrophage inflammatory
protein-3 alpha from normal and transformed cells. |
|
|
| | |
| 115498 | CCL20 | Protein | Homo sapiens | Bind | direct | CCR6 | Protein | Homo sapiens | | | In contrast to other chemokines, including
MCP-1 and IL-8, the natural processing did not affect the
calcium-mobilizing capacity of LARC/MIP-3alpha through its
receptor CCR6. | | | |
Interaction id | 115498 | |
MOLECULE A | |
Id | 6364 |
Type | Protein |
Species | Homo sapiens | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 1235 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Bind (
direct ) | |
Pathway | Cytokine And Chemokine Mediated Signaling Pathway | |
Interaction result | |
Other Resultant | | Regulate calcium mobilization |
| |
References | |
PubMed Id | 11035086 | |
Author | Schutyser E, Struyf S, Menten P, Lenaerts JP, Conings R,
Put W, Wuyts A, Proost P, Van Damme J | |
Title | Regulated production and molecular diversity of human liver
and activation-regulated chemokine/macrophage inflammatory
protein-3 alpha from normal and transformed cells. |
|
|
| | |
| 192711 | NF-kappa-B | Multi subunit | Homo sapiens-e | Increases expression | direct | CCL20 | Protein | Homo sapiens-e | | | To investigate whether PEDF also modulates
gene expression in astrocytes, we employed the use of RT-PCR
to analyze the gene expression of certain pro-inflammatory
genes and found that genes such as IL-1 beta, IL-6,
TNF-alpha, MIP1 alpha, and MIP3 alpha were induced in
PEDF-treated cultured neonatal astrocytes, but not in adult
astrocytes. / These results suggest that the induction of
pro-inflammatory genes is mediated via activation of
NF-kappa B, AP-1, and CREB in neonatal astrocytes. | | | |
Interaction id | 192711 | |
MOLECULE A | |
Id | TRHsM00001 |
Type | Multi subunit |
Species | Homo sapiens-e | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 6364 |
Type | Protein |
Species | Homo sapiens-e | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Increases expression (
direct ) | |
Pathway | Regulation of transcriptionImmune Response:Inflammatory Response | |
Experimental location and method | - condition::SERPINF1 treated neonatal astrocytes
- cell::Astrocytes
| |
References | |
PubMed Id | 15739190 | |
Author | Yabe T, Sanagi T, Schwartz JP, Yamada H | |
Title | Pigment epithelium-derived factor induces pro-inflammatory
genes in neonatal astrocytes through activation of NF-kappa B
and CREB. |
|
|
| |
|
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