| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 112154 | Tacrolimus | Small molecule | Small molecule | Inhibits expression | indirect | TNF | Protein | Homo sapiens | | | CSA also potently inhibited the production of
IL-15 and TNFalpha stimulated with interferon-gamma,
IL-1beta, or lipopolysaccharide. / Results with the
calcineurin inhibitor FK-506, but not with the
immunosuppressant rapamycin, were similar to those with CSA. | | | |
Interaction id | 112154 | |
MOLECULE A | |
Id | 104987-11-3 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | -- | |
MOLECULE B | |
Id | 7124 |
Type | Protein |
Species | Homo sapiens | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | - | |
|
General Information |
Interaction term | Inhibits expression (
indirect ) | |
Pathway | Response to Stimulus:Response to Drug | |
Disease Details | | disease: :Arthritis, Rheumatoid |
| |
Experimental location and method | - Experimental method::Enzyme-Linked
Immunosorbent Assay
- species::Human
- condition::Rheumatoid arthritis patient
- cell::Fibroblast-like synoviocytes
| |
References | |
PubMed Id | 11817607 | |
Author | Cho ML, Kim WU, Min SY, Min DJ, Mi, n JK, Lee SH, Park SH,
Cho CS, Kim HY | |
Title | Cyclosporine differentially regulates interleukin-10,
interleukin-15, and tumor necrosis factor a production by
rheumatoid synoviocytes. |
|
|
| |
|
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