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Here, we report that inhibition of ERK1/2
increased the basal activity of GSK3beta in cortical neurons
and that both ERK1/2 and PI3K were required for
brain-derived neurotrophic factor (BDNF) suppression of
GSK3beta activity. / Interestingly, PI3K (but not ERK1/2)
induced the inhibitory phosphorylation of GSK3beta at Ser-9.