| Interaction ID | Mol A | Type | Species | Verb | Nature | Mol B | Type | Species |   |
|---|
|
| 95405 | Betamethasone | Small molecule | Small molecule | Decreases release | indirect | Tnf | Protein | Mus musculus | | | We have investigated the effects of
betamethasone, cyclosporin, and nedocromil on MMP2 and MMP9
activities, on TNF-alpha and IL-10 release, as well as on
the recruitment of inflammatory cells in the bronchoalveolar
lavage (BAL) fluid after aerosol administration of
lipopolysaccharide (LPS) in mice. When mice were pretreated
with betamethasone (5 mg/kg, po), MMP2 and MMP9 activities,
TNF-alpha in BAL fluids, and the enhanced neutrophil number
of LPS-exposed mice were reduced, whereas the level of IL-10
was increased. | | | |
Interaction id | 95405 | |
MOLECULE A | |
Id | 378-44-9 |
Type | Small molecule |
Species | Small molecule | |
Attribute |
--
|
Structure Details | -- |
Disease Details | disease: :Acute lung injurysignificance: :Therapeutic potential | |
MOLECULE B | |
Id | 21926 |
Type | Protein |
Species | Mus musculus | |
Attribute | -- |
Structure Details | -- |
Disease Details | -- | | Kinetics | | Mol A | | Conc | Time | Others | Comments | 5mg/kg
| | | Oral administration
|
|
| |
|
General Information |
Interaction term | Decreases release (
indirect ) | |
Pathway | Immune Response:Inflammatory ResponseCytokine And Chemokine Mediated Signaling
Pathway:TNF Signaling Pathway | |
Disease Details | | disease: :Acute lung injury |
| |
Experimental location and method | - species::Mouse
- condition::lipopolysaccharide exposed mouse
- organ / tissue::Bronchoalveolar lavage fluid
| |
References | |
PubMed Id | 10419836 | |
Author | Corbel M, Lagente V, Theret N, Germain N, Clement B,
Boichot E | |
Title | Comparative effects of betamethasone, cyclosporin and
nedocromil sodium in acute pulmonary inflammation and
metalloproteinase activities in bronchoalveolar lavage fluid
from mice exposed to lipopolysaccharide. |
|
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| |
|
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